Boston Outstanding Business Development

Living up to the trust of customers by delivering impactful results.

About Us

Boston Outstanding BD Consulting, LLC is a Boston-based life science business-development boutique led by Yan Zhou - MD&PhD, a former Clinical Pathologist, Principle Investigator, Biomarker Scientist, CRO BD lead with 15 years' experience across preclinical and clinical asset research, development, and partnerships.

Our Mission

To be the bridge between innovative science and global markets—closing deals that accelerate therapies to patients.

Our Vision

A world where every promising preclinical asset finds the right development partner and funding to make an impact.

Leadership

  • Yan Zhou - MD&PhD, Founder & CEO, about 4 years in small-molecule & biologics BD; 40+ clients partnerships; Closing deals valued at over $10 Million. Deep expertise in immuno-oncology and metabolic field partnerships.
  • Core Advisor Team - Three advisors who have successfully completed 10 major Business Development deals in oncology and metabolic disease (over $3 billion upfront fee total).

Core Values

  • Integrity
  • Client-first responsiveness
  • Long-term relationships

Key Capabilities

Strategic Partner Identification

  • Deep network of 40+ active biotech, pharma, and VC contacts
  • Targeted outreach powered by data-driven mapping of unmet needs

Deal Structuring & Negotiation

  • Expertise in tiered fee & royalty models, milestone-based payments
  • Track record of $50M IND-stage term sheets and licensing deals

Cross-Border Licensing & Market Entry

  • U.S.-China gateway: regulatory, legal, and cultural fluency
  • Local representation, from pre-IND through Phase III/commercialization

Capital Raising & Investor Relations

  • Investor introductions (VCs, strategic pharma partners)
  • Crafting pitch decks, financial models, and due-diligence support

Contract Research Organization (CRO) Services

Deep-dive into our service categories, tailored to your modality of interest.

Small-Molecule

  • Medicinal-Chemistry scouting & target identification & Hit validation & Lead optimization, process Chemistry, CMC analysis (GMP/non-GMP)
  • Biology/DMPK/ADME/Tox profiling (GLP/non-GLP)
  • Custom synthesis & scale-up to commercialization (mg → kg)
  • Formulation development (solubility, stability, GMP/non-GMP)

Large-Molecule (Biologics)

  • Antibody discovery, sequence optimization, PH, cross species binding, scFv stability improvement/stabilization, humanization & engineering
  • Biology, Cell-based assay development (PK/PD)
  • Biologics CMC: expression, purification, analytics (GMP/non-GMP)
  • PK/ADA immunogenicity studies (rodent, NHP)

Nucleic-Acid Therapies

  • Oligonucleotide design & screening
  • LNP formulation and characterization
  • Delivery & biodistribution studies
  • RNA-seq & biomarker assay development

All services are backed by our network of top-tier CROs in the U.S. and China, rigorously vetted for quality and timeline performance.

Our Assets

Preclinical Drug Candidates (Assets)

A curated showcase of our preclinical pipeline and partner-sourced assets.

We help source, license, and co-develop novel assets in three key indications:

Metabolic Disease

  • Obesity (ActRII, mAb) — completed rodent efficacy in Q3 2025.
  • Obesity (Myostatin, mAb) — completed rodent efficacy in Q3 2025.
  • Obesity (GIPR/GLP-1RA, mAb/fusion protein) — completed rodent efficacy in Q3 2025.

Oncology

  • BTLA, mAb — completed rodent efficacy in Q3 2025.

Autoimmune Disease

  • BAFF-R, mAb — completed rodent efficacy models.

Chronic Kidney Disease

  • Cyclophilin Inhibition — Small molecular/ IND filing by the end of 2025.

Interested in co-development or licensing? Contact us to review data packages and term-sheet templates.

Success Stories

Precision Client Acquisition & Multi-Project Collaboration

Client Background:

A specialized client from a new region with no prior experience working with Chinese CROs before initial contact.

Strategy:

  • Identified and connected with target client via LinkedIn and other channels
  • Established preliminary trust through virtual meetings, followed by executive-level onsite visit to client HQ at optimal timing
  • Secured first project rapidly, opening collaboration pipeline

Trust-Building & Project Expansion:

  • Provided rapid response during first project delivery, conducting multiple virtual/onsite meetings to clarify requirements
  • Arranged lab tours and facilitated quality system audits
  • Received exceptional service evaluation and outstanding project results, leading to swift initiation of multiple cross-departmental follow-up projects

Outcomes:

  • Transitioned client from initial contact to comprehensive collaboration
  • Cumulative project value reached ~$2 million USD
  • Established long-term trusted partnership with ongoing internal referrals

Global Leading Biotech's China Audit & NHP Project Strategy

Client Background:

A $10B+ market cap global biotech leader actively seeking China-based CRO partners with both GLP and non-GLP capabilities, particularly focusing on establishing non-human primate (NHP) research capacity.

Objectives:

Support client's first formal GLP/non-GLP audits in China, build long-term trust, and advance early-stage evaluation/planning for local NHP projects (potential value >$10M).

Execution:

Initial Contact:

Established connection with client executives at an international biopharma conference (Nov 2022). Despite initial disinterest, maintained regular communication to gradually facilitate executive-level dialogue.

Strategic Opportunity:

Capitalized on Cambodia wild monkey trade disruption (Feb 2024) which severely impacted NHP imports (e.g., Charles River project suspension), prompting client to urgently reevaluate global supply chains and consider China-based alternatives.

Implementation:

Coordinated compliant CRO audits and submitted competitive NHP project proposals/timelines to strengthen trust.

Results:

  • Successfully completed client's first China GLP/non-GLP audits
  • Potential project value exceeding $10 million
  • Significantly enhanced client confidence in China's preclinical platforms, laying foundation for strategic long-term collaboration

Enabling Small-Molecule Biotech's ADC Antibody Discovery Partnership

Client Background:

A US-based small biotech specializing in small-molecule targeted therapies, exploring ADC platform development but lacking macromolecule resources/partner network.

Services:

  • Analyzed client strategy and recommended antibody discovery as entry point
  • Custom-matched macromolecule platform partners and facilitated collaboration setup
  • Advised on service scope, pricing, and timelines to reach agreement

Outcomes:

  • Initiated first antibody discovery project within 3 months of engagement
  • Positive client feedback leading to planned ADC conjugation/optimization services
  • Partner acknowledged client's professionalism and long-term potential

Project Timeline:

Completed entire process from strategic consultation to project launch in 3.5 months

Contact Us

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Email: yan@bobd.group

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